The Internet is global…
Yes, if you did not know this so far, I am writing it clearly: the internet is gobal.
Our main office is in Romania, Eastern Europe, but we run a few region specific B2B portals like Brazil B2B Marketplace or Middle East B2B Portal. We are getting more and more recognition through these regional portals, local and regional media is started to be interested is us and our work.
Today, we got a serious partnership proposal from a well know publishing company from Middle East. They are interested to partner and work together with us and … will see what will happen. And, I have to tell you that this is not the first similar proposal we got from well known Middle East Companies. So, it looks like it doesn’t matter too much where you are located or have your main offices if you do your job. 
Yes, of course, similar requests will certainly lead us sooner or later to establish a local presence in a specific region, but the above scenario confirms that this is certainly not a must… yet.